Mathematical modelling of drug-resistance in microorganisms and cancers

The College of Life and Environmental Science wishes to appoint a Postdoctoral Researcher to participate in an exciting interdisciplinary collaboration between mathematical modelling groups of Dr Ivana Gudelj and Professor Robert Beardmore, University of Exeter and Computational Biology and Oncology Departments at AstraZeneca, Cambridge. This full-time post is available from 1^st July 2014 for the period of two years. The successful applicant will contribute towards research that uses concepts from ecology and Darwinian evolution applied to microorganisms, to understand the strength of natural selection in cancer cells. scholarship daily news in www.rightman.ir

This project will take a data-driven mathematical-empirical modelling approach to study the evolutionary dynamics of resistance to chemotherapy. Our goal is to give an improved quantitative and mechanistic understanding of the evolutionary mechanisms that underpin the emergence of drug resistance. Mathematical models will be supported by AstraZeneca using bespoke, in-house datasets. scholarship daily news in www.rightman.ir

The successful applicant will be working on the development and analysis of mathematical models in Dr Gudelj’s and Professor Beardmore’s labs at the University of Exeter, in close collaboration with colleagues at AstraZeneca, Cambridge. Applicants will possess a PhD in a quantitative discipline (mathematics, physics, engineering or computer science) or equivalent in a related field of study and be familiar with ordinary differential equations, their use in modelling, analysis (Dynamical Systems techniques) and simulation. An ability to programme in Matlab, C++, Python or other high-level programming language is essential. The successful candidate should have a genuine interest in biological problems and be able to communicate effectively with individuals from a wide range of disciplines. scholarship daily news in www.rightman.ir

The College is working towards department Silver Athena SWAN awards as a commitment to providing equality of opportunity and advancing the representation of women in STEM/M subjects: science, technology, engineering, mathematics and medicine. scholarship daily news in www.rightman.ir

We welcome applications from candidates interested in working part-time hours or job-sharing arrangements. scholarship daily news in www.rightman.ir

Interviews are expected to be held in the week commencing 24^th June 2014. scholarship daily news in www.rightman.ir

Relevant reference

Beardmore R. E.*, Gudelj I.*, Lipson D. A., Hurst L. D. (2011) Metabolic trade-offs and the maintenance of the fittest and the flattest. Nature, 472, 342-346. scholarship daily news in www.rightman.ir

Pena-Miller R., Laehnemann D., Jansen G., Fuentes-Hernandez A., Rosenstiel P., Schulenburg H., Beardmore R. (2013) When the Most Potent Combination of Antibiotics Selects for the Greatest Bacterial Load: The Smile-Frown Transition. PloS Biology, 4, e1001540 scholarship daily news in www.rightman.ir

Maharjan R., Nilsson S., Sung J., Haynes K., Beardmore R. E., Hurst L. D., Ferenci T. and Gudelj I. (2013) The form of a trade-off determines the response to competition. Ecology Letters, 16, 1267-1276. scholarship daily news in www.rightman.ir

For further information please contact Dr Ivana Gudelj (e-mail [email protected]) or Professor Robert Beardmore (e-mail: [email protected]) or visit http://people.exeter.ac.uk/ig232/Home.html ; http://people.exeter.ac.uk/reb217/home.html

The starting salary will be from £25,014 up to £28,133 on Grade E, depending on qualifications and experience. scholarship daily news in www.rightman.ir

The closing date for completed applications is 17^th June 2014. scholarship daily news in www.rightman.ir

The University of Exeter is an equal opportunity employer which is ‘Positive about Disabled People’. Whilst all applicants will be judged on merit alone, we particularly welcome applications from groups currently underrepresented in the workforce. scholarship daily news in www.rightman.ir

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